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Metoclopramide dosage and route of administration are not the same. Ingestion of 200 mg IV paroxetine may produce significant dose-dependent increase in Cmax compared to 150 mg IV paroxetine. Thus, in patients who have been prescribed 500 mg daily paroxetine dosage, taking a higher dosage and lower of paroxetine with meals may be considered. A possible advantage of the present invention over conventional agents for the treatment of major depressive disorder may be obtained with the combined administration of paroxetine and mirtazapine, e.g., 200 mg paroxetine and 300 mirtazapine twice daily. In particular, an improvement outcome patients having depression or bipolar affective disorder (bipolar depression or major depressive disorder) may be expected when the mirtazapine is given concomitantly with the paroxetine. However, because the two agents must co-administer and because mirtazapine is only slightly more potent than paroxetine, the simultaneous administration of mirtazapine with paroxetine or vice versa does not lead to any additive effect that makes the combined drug better for depression than either agent alone. The mirtazapine should be started with 300 mg paroxetine, taken once a day (or at least once every day if desired); mirtazapine might be considered a first-line agent for the treatment of major depressive disorder in patients who are taking conventional antidepressant therapy. A further disadvantage for the preparation of paroxetine combined treatment major depressive disorder and bipolar depression is that paroxetine requires acheter zolpidem en espagne the preparation of a new and relatively expensive drug preparation in order to provide the antidepressant effect of paroxetine with that achieved from one dose of paroxetine. If the second drug is too high, it may produce undesired effects; for instance, the onset or incidence of some the gastrointestinal side effects of paroxetine may occur. The combination of paroxetine and either mirtazapine or another serotonin reuptake inhibitor, e.g., fluoxetine, also provides an improved antidepressant effect but also results in a significantly higher cost of preparation the mixture. For these reasons it was decided to produce in accordance with the invention a single compound of this invention comprising paroxetine and another agent that increases monoamine neurotransmitter uptake into and facilitates the function of cells that are not involved in the regulation but are involved in cell signaling which is a normal function of the human brain such as fluoxetine, an inhibitor of cAMP, adenylylated cyclic nucleotide receptors and selective specific inhibitors of monoamine transporters such as and phosphodiesterase (PDE; e.g. PDE6), inhibitors such as mirtazapine, serotonin reuptake inhibitors, selective and nonselective serotonin receptor antagonists or selective and non adrenergic agonists or antagonists. The present invention also contemplates preparation of this single compound invention in a pharmaceutically acceptable method, according to the specific embodiment herein described. When this compound, comprising paroxetine and a second compound such as fluoxetine, is administered in the form of a combination, it forms combination of paroxetine and a single agent for antidepressant treatment in the form of a pharmacologically acceptable carrier, for instance a pharmaceutically acceptable water-soluble soluble compound in the form of a solution or suspension; pharmaceutically acceptable oil, a liquid or gel form suitable for oral administration; or any other suitable method carrier, for instance a pharmaceutical formulation. The particular method that is used in combination with one single active ingredient (such as paroxetine) to produce any desired pharmacological effect is described in the individual specification that corresponds to the present invention. For example, single paroxetine may be administered in the form of a single pill or capsule, in the form of 2 pills and administered as part of a combined therapy (e.g., in daily medication regimens of paroxetine 200-300 mg, or in a monthly medication regimen of paroxetine 40 mg and fluoxetine 20 mg); the single may be administered in the form of 4 capsules administered once a day in the form of 50 mg daily. The specific methods which constitute a combination of paroxetine and pharmaceutical formulation are described in the individual specification corresponding to present invention. For example, the single paroxetine may be administered as a single tablet at dose of 150 mg daily or as a preparation of 1 milligram (4 mg) and mg. Alternatively, 1 milligram (4 mg) dose of paroxetine/2 milligram (4 mg) dose of fluoxetine may.
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